Email

SMTP v. API: Their differences and how to use them

We get it – when it comes to email, certain terms can sometimes feel like word salad. This is especially true for the acronyms SMTP and API. It can be hard to keep these terms straight, and even harder to know when to use them. But no worries, we’ve got you. In this post, we’ll teach you the differences between SMTP and API, and when to use each.
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September 15, 2025

You’re tasked with integrating email into the app you’re building or the customer relationship management (CRM) tool your business uses. You have two options: traditional SMTP or an SMTP API, which uses HTTP requests (often RESTful and JSON formatted) for faster and more flexible email sending and management. Both are crucial to your email development and deployment process, whether you’re sending an email marketing campaign or a triggered transactional email. But what are they, and when do you use each?

What is SMTP?

We’re diving right in and tackling SMTP first. What is it, and how do you use it?

SMTP stands for Simple Mail Transfer Protocol, and it’s the method of sending emails across the internet. An SMTP server lets you use SMTP to transfer mail through a server and across a network to its destination. Unlike most computer servers that handle multiple processes at any given time, an SMTP server is only used to send, receive, and transfer email. Mailgun acts as an intermediary to send mail via SMTP, as shown below:

SMTP flowchart

How is SMTP used?

SMTP is designed specifically for one job – sending emails. It handles the transfer of messages from the sender’s server to the recipient’s server, ensuring reliable delivery.

When sending via SMTP, you may wonder which SMTP port to choose. Port 587 is considered the default SMTP port for mail transfer. You should use it, unless your network or provider blocks you.

What are some pros and cons of using SMTP to send emails?

Now that you know the basics of SMTP, let’s go over some advantages and disadvantages of using SMTP to send emails.

Here are three disadvantages to using SMTP:

  • Slow performance for large volumes of email: SMTP relay requires a lot of back and forth between the sending email client and the receiving server to perform various checks and authentications. This means delays and slow performance, especially when you’re sending large volumes of emails.
  • Changing deliverability of emails: Most SMTP relay services use shared IP addresses, which affect your sender reputation. This means you won’t experience a consistent sender reputation or consistent deliverability. In turn, this affects the effectiveness of your email campaign and puts a severe dent in key marketing metrics like open rates, conversion rates, and click-through rates. To fix this, you’ll need to implement major Domain Name Service (DNS) adjustments.
  • Possible blockage of Port 25: While Port 587 is the recommended default for SMTP mail transfer, some email clients and ISPs block Port 25 due to its frequent abuse by spammers. Using Port 25 for SMTP increases the risk of delays or your emails being flagged as spam – stick with Port 587 instead.

But SMTP isn’t all drawbacks. Here are three key advantages of using SMTP relays to send emails:

  • Easy platform migration: Because SMTP relays are platform-independent, moving them between systems is simple. This flexibility helps “future-proof” your email workflow.
  • Easy to set up: SMTP relays are much easier to set up than email APIs. In fact, most email service providers (ESPs) set up SMTP relays and SMTP servers.
  • Simpler to troubleshoot: Due to the back-and-forth nature of an SMTP relay, you’ll get a response code every step of the way. This makes troubleshooting much easier than for email APIs.

What is email API?

Now that we know about SMTP, let’s dive into the basics of API. When used for email, email APIs are similar to SMTP in sending messages, but they provide more flexible, comprehensive integration options beyond just routing emails through SMTP. This allows APIs to enable automated, triggered email actions and additional features not typically available with SMTP.

API stands for Application Programming Interface, and, unlike SMTP, it’s used for more than just email. API is software that enables multiple applications and systems to communicate, usually through the Hypertext Transfer Protocol (HTTP). For example, when you login to an online account, an HTTP API tells the account’s system that you’re trying to login and then tells you if the login attempt was successful.

It can be used for many applications, but we use it for email. If you send a message in a Mailgun emailing context, you’re using a web API to generate, queue, and send your message.

How is an email API used?

While an API is used for lots of different applications and actions, we’ll focus on email APIs. With email APIs, a given application, like a product website, can use the API to automatically send transactional mail (like receipts and confirmations) without having to queue and send each individually.

When a product website uses Mailgun, it embeds code into applications like signup forms or checkout pages. When a triggered action occurs, the code sends an API request to Mailgun, instructing it to generate and deliver the correct email to the intended recipient using the website’s data, such as an email list.

Mailgun API code

All email APIs work similarly to this example. Their purpose is to provide fast, consistent email capabilities without the hassle of using a separate provider or software. To facilitate ease of use, Mailgun’s RESTful API allows developers to use their coding language of choice rather than dealing with the headache of finding a provider that uses their specific language to facilitate ease of use.

What are some pros and cons of using an email API?

Now that you know the basics of API, let’s go over some advantages and disadvantages of using API to send emails.

Here are three disadvantages to using an email API:

  • Steep learning curve: Each email API is unique and has a learning curve before you can perfectly integrate it into your app.
  • Third-party intermediaries: Each email API is managed by external ESPs like Mailgun, so you need to trust the provider to handle your email reliably and securely.
  • Need coding knowledge to troubleshoot: While SMTP provides you with response codes every step of the way, email APIs require coding knowledge to properly troubleshoot.

That being said, here are some advantages to using an email API:

  • Reduces complexity in your app: That’s right. Since email APIs are provided by third-party intermediaries, you’re not responsible for their maintenance or building. Instead, you simply need to integrate it into your app.
  • Removes load from your servers: Since ESPs provide email APIs as a service, the email-sending load defaults to their servers instead of yours. This increases your email deliverability and decreases send times.
  • Get analytics on your email sending: Most ESPs enable you to easily collect analytics on your email practices, including open rates, click-to-open ratio, and click-through rates.
  • Advanced features: APIs provide the flexibility to manage large attachments seamlessly, which is particularly beneficial for businesses sending detailed reports or multimedia content. 
  • Real-time analytics and feedback: Users can monitor open rates, click-through rates, and other engagement metrics in real-time, enabling immediate optimization of email campaigns. 
  • Reduced likelihood of email blocking: APIs use authenticated connections and adhere to best practices that reduce the chances of emails being marked as spam or blocked altogether. 
  • Security enhancements with Web API: API keys ensure that only authorized applications can send emails, reducing the risk of unauthorized usage and enhancing overall security. 
  • Latency reduction for international users: By minimizing the back-and-forth communication required in SMTP, APIs ensure faster email delivery times for international recipients. 

SMTP vs. API at a glance

Feature / Factor SMTP Email API 
Ease of setup ✅ Easier to set up, often preconfigured by ESPs ❌ Requires coding knowledge and integration effort 
Migration ✅ Platform-independent, easy to migrate ❌ Migration may require app adjustments 
Troubleshooting ✅ Response codes make troubleshooting straightforward ❌ Requires coding skills to troubleshoot issues 
Performance (high volume emails) ❌ Slower due to multiple server checks ✅ Faster, optimized for bulk sending 
Deliverability consistency ❌ Shared IPs can affect sender reputation ✅ Typically consistent, managed by ESP 
Port issues / spam risks ❌ Port 25 may be blocked or flagged by ISPs ✅ No port issues; handled via API 
Server load ❌ Uses your servers for sending ✅ Load handled by ESP, improves performance 
Analytics / tracking ❌ Limited built-in tracking ✅ Provides detailed email analytics 
Learning curve ✅ Simple and standardized ❌ Steep, each API is unique and requires learning 
Reliability / automation ✅ Standardized protocol, widely supported ✅ Reliable and easy to automate with triggers 

When should you use SMTP v. API?

SMTP and API may seem similar, but they serve distinct purposes: SMTP uses a series of text-based commands to transfer mail, while an SMTP API offers a faster, more flexible, and developer-friendly interface by utilizing RESTful HTTP requests for smoother and more efficient email delivery.

SMTP and API both have applicability when it comes to email. However, there’s one that we here at Mailgun recommend over the other. Let’s take a look.

When should I use SMTP for email?

We recommend using SMTP if you’re a sender that can’t add API to your applications. This includes applications specifically developed for you by a third party that can’t integrate with API. Additionally, you may have an older system or sending method that’s using SMTP – in that case, it may save you time, money, and energy to keep using SMTP instead of migrating to a new ESP. If it’s not worth it, save yourself the trouble.

As we mentioned, Port 587 is generally what you should use to send emails via SMTP, but you may need another port if you’re blocked or otherwise have a problem with your network.

You can use SMTP for transactional or bulk email. The disadvantage of SMTP is it tends to be slower than API – there’s a lot more “talking” between servers. This can lead to lower-performing mail sending.

When should I use an API for email?

We recommend using an API for email whenever possible, as APIs involve less back-and-forth communication between servers than SMTP relays, making them faster and more efficient. Like SMTP, APIs support bulk and transactional emails, but their streamlined process provides greater flexibility and improved performance for sending large volumes.

For example, if you’re an online shopping retailer, you should provide relevant email receipts, shipping notifications, and other transactional email messages. Of course, you probably don’t have the time or desire to send these emails to your hundreds (or thousands, or millions) of customers individually.

With an email API, you can leverage various features to automate sending and tie messages to triggered actions. Unlike SMTP, you can easily code an API to do what you want, when you want it. A purchase is made? Email a receipt. A shipping order is placed? Automatically send a tracking number or location updates. This saves you the crazy hassle of manually updating and sending messages, streamlines your service lifecycle, and strengthens your customer relationships.

Automated confirmations and receipts build customer trust and encourage repeat business. Any message that reduces friction in the customer journey is valuable, and an email API makes it easy to deliver these communications reliably and efficiently.

How do I get started with an email API?

Now that you know a little more about SMTP vs. API, go forth and email with confidence. You’ll know what method is right for you, and you’ll have two less acronyms to worry about. Interested in more explanatory articles like this? Check out our thoughts on parallel programming, Gmail open tracking, and email rendering.

If you’re ready to start sending, check out our powerful email API and see how we can supercharge your email campaigns today.

SMTP vs. API: FAQs

Authentication for email isn’t tied to the protocol (SMTP vs. API) as much as it is to your sending domain. Regardless of how you send, you’ll want to: 

  • SPF: Add a DNS TXT record that authorizes your email service provider (ESP) to send on your behalf. For Mailgun, that means including the Mailgun mechanism in your SPF record. 
  • DKIM: Publish a public key in your DNS and let your ESP sign outgoing messages with the private key. This ensures the messages can’t be altered in transit. 
  • DMARC: Set up a DMARC policy in DNS to instruct inbox providers how to handle messages that fail SPF or DKIM checks. Start with “p=none” to monitor, then move to “quarantine” or “reject” once you’re confident. 

These records live in your domain’s DNS regardless of whether you send via SMTP or API. Once they’re in place, Mailgun (or another ESP) automatically applies them to outbound mail. 

Strictly speaking, SMTP itself isn’t RESTful; it’s a protocol. But many email providers – including Mailgun – expose a RESTful email API that developers can call instead of using SMTP. 

  • Python: This blog post walks through using Mailgun’s REST API with the requests library. 
  • Node.js: This blog post covers a working sample using the official SDK. 

If you must use SMTP, most languages support it through built-in libraries (smtplib for Python, nodemailer for Node.js). The main difference is you’ll connect to an SMTP host/port and pass credentials instead of hitting an HTTP endpoint. 

Look for these features (Mailgun and other top ESPs provide them): 

  • Delivery logs & dashboards: Real-time logs of accepted, delivered, failed, or delayed messages. 
  • Webhook alerts: Push notifications when bounces, complaints, or failures occur. 
  • Response codes: SMTP gives you codes at each step of the handshake. APIs often provide JSON status objects. 
  • Inbox placement tests: Some providers integrate with seed-list testing tools to see where your email lands. 
  • Reputation monitoring: Many ESPs surface your sending IP/domain reputation inside the dashboard. 

Combining these helps you spot problems quickly – whether that’s a blocked port, a failing DKIM signature, or a content issue triggering spam filters. 

Pricing and throughput differ by vendor but you’ll typically see: 

  • SMTP relay: Often included “free” with hosting or ESP plans but slower, with implicit limits (connections per second, per-message size). 
  • Email APIs: Usually priced per 1,000 emails sent, with higher tiers unlocking faster send rates and dedicated IPs. APIs tend to support higher concurrency than SMTP because they’re stateless HTTP calls rather than open socket connections.

For example, Mailgun’s entry tiers give you thousands of API calls per month with defined rate limits; higher-volume plans provide dedicated infrastructure and priority sending. Always check your provider’s published send-rate limits to avoid throttling. 

Migrating is usually straightforward if you plan it out: 

  1. Audit your current SMTP usage: List every app, cron job, or integration that sends mail. 
  2. Set up your API credentials & DNS records: Make sure SPF, DKIM, and DMARC are configured for your domain before cutover. 
  3. Implement the API in a staging environment: Start with triggered or low-volume sends. 
  4. Monitor analytics & deliverability: Compare bounce/complaint rates between SMTP and API to confirm the new setup. 
  5. Gradual switchover: Migrate transactional mail first (password resets, receipts), then bulk/marketing messages once stable. 
  6. Retire old SMTP credentials: Rotate or revoke SMTP passwords to prevent accidental use once the API is live. 

This phased approach minimizes downtime and lets you take advantage of faster sending, better analytics, and more flexibility as soon as possible.